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KMID : 0371619870030010135
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Journal of Wonkwang Medical Science
1987 Volume.3 No. 1 p.135 ~ p.146
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Effects of Chijadaewhngtang Extract, Inchinchijatang Extract on Hepatotoxicity in Rats
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Abstract
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An attempt was made to evaluate the effects of Chijadaewhangtang extract (CDE) and Inchinchijatang extract (ICE) on the recovery of hepatotoxicity induced acute treatment of carbon tetrachloride and results were as follows:
1. When rats of carbon tetrachloride-intoxication were treated with CDEand ICE, the serum aspartate aminotransferase activities released from liver were decreased. In ICE treated group, there were significant decrement after 72 hours and more fast return to normal values in comparison with CDE treated group.
2. In CDE and ICE-treated group, as compared with only carbon tetrachloride-treated group there were inhibition of serum alanine aminotransferase elevation and significant decrement was observed in ICE treated group after 48 hours and CDE treated group after 72 hours.
3. Serum alkaline phosphatase values were significantly diminished in CDE and ICE?-treated group compared with only carbon tetrachloride intoxicated group. Meaningful diminution was observed in ICE administered group after 48 hours and CDE administered group after 96 hours.
4. Significant decrement of serum lactate dehydrogenase elevation after 96 hours was observed in CDE and ICE-treated group and more fast recover to normal values.
5. Administration of CDE and ICE shortened proth:ombiu time of plasma and significant recovery was showed in ICE treated group after 72 hours and CDE treated group after 96 hours.
From these results, the recuperative effects of CDE and ICE on carbon tetrachloride-induced hepatotoxicity could be verified experimentally.
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